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Substitution Spectrum and Selection at G-quadruplexes in Great Ape Telomere-to-Telomere Genomes.

Genome biology and evolution - 2 Mar 2026

Zhang Xinru, Mohanty Saswat K, Chiaromonte Francesca, Makova Kateryna D

Abstract excerpt

G-quadruplexes (G4s) are noncanonical DNA secondary structures formed by runs of guanines (stems) connected by other nucleotides (loops). These structures are enriched at regulatory regions such as promoters, CpG islands, untranslated regions (UTRs), enhancers, and replication origins, where they play key roles in transcription and replication. Although prior studies have demonstrated that G4s exhibit higher...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41746207
DOI: 10.1093/gbe/evag040
PMCID: PMC12980574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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