Article

Graves’ disease-associated TSHR gene is demethylated and expressed in human regulatory T cells

2022-10-25

Abstract excerpt

Epigenetic changes at specific genetic loci and the activation of transcriptional repressor FOXP3 are needed to establish and maintain the regulatory T cell (Treg) lineage. Here we studied the DNA methylation profiles in CD4 + CD25 + Tregs and CD4 + CD25 − conventional T cells (Tconvs) from healthy individuals and identified a wide range of differentially methylated CpG sites (DMPs). Overall, Tregs had more hy...

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Literature Corpus work: 7439a1c6-6343-53c9-a1ed-c21b2c4cfda5
DOI: 10.1101/2022.10.24.513489

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