Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic silencing of TSHR gene in thyroid cancer patients in relation to their BRAF V600E mutation status.

Endocrine - 1 Nov 2014

Khan Mosin S, Pandith Arshad A, Masoodi Shariq R, Wani Khursheed A, Ul Hussain Mahboob, Mudassar Syed

Abstract excerpt

Promoter hypermethylation of multiple genes have been identified to play a role in thyroid cancers and most prominent among them is TSHR gene promoter hypermethylation in particular showing a close association with BRAF gene-altered status. Thus, the aim of this study was to analyze the TSHR gene promoter hypermethylation in a series of thyroid tumor tissues in the backdrop of their BRAF gene mutational status....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma, Follicular
Share to Carcinoma, Papillary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Silencing

Share to MAP Kinase Signaling System

Share to Proto-Oncogene Proteins B-raf

Share to Receptors, Thyrotropin

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 24927793
DOI: 10.1007/s12020-014-0319-6

Genes

TSHR
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic silencing of TSHR gene in thyroid cancer patients in relation to their BRAF V600E mutation status.PMID 24927793Read ↗

TSH signalling and cancer.Semantic proximity Read ↗

Graves’ disease-associated TSHR gene is demethylated and expressed in human regulatory T cellsSemantic proximity Read ↗

Association of DNA Promoter Methylation and BRAF Mutation in Thyroid Cancer.Semantic proximity Read ↗

Early occurrence of RASSF1A hypermethylation and its mutual exclusion with BRAF mutation in thyroid tumorigenesis.Semantic proximity Read ↗

Different expression of TSH receptor and NIS genes in thyroid cancer: role of epigeneticsSemantic proximity Read ↗

Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid CarcinomaSemantic proximity Read ↗

DNA Methylation in Thyroid TumorigenesisSemantic proximity Read ↗

Hypermethylation of the RSK4 promoter associated with BRAF V600E promotes papillary thyroid carcinoma.Semantic proximity Read ↗

Cancer risk and clinicopathological characteristics of thyroid nodules harboring thyroid-stimulating hormone receptor gene mutations.Semantic proximity Read ↗

TSHR rs2288496 associated with thyroid hormone and predict the occurrence of lymph node metastasis of papillary thyroid cancer.Semantic proximity Read ↗

Methylation of tumour suppressor genes associated with thyroid cancerSemantic proximity Read ↗

RASSF1A and NORE1A methylation and BRAFV600E mutations in thyroid tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.