Article
TSHR Gene Polymorphisms in the Enhancer Regions Are Most Strongly Associated with the Development of Graves' Disease, Especially Intractable Disease, and of Hashimoto's Disease.
Thyroid : official journal of the American Thyroid Association - 1 Jan 2017
Fujii Asami, Inoue Naoya, Watanabe Mikio, Kawakami Chisa, Hidaka Yoh, Hayashizaki Yoshihide, Iwatani Yoshinori
Abstract excerpt
BACKGROUND: Graves' disease (GD) and Hashimoto's disease (HD) are autoimmune thyroid disorders distinguished by the presence or absence of antithyrotropin receptor (TSHR) antibodies (TRAb). TSHR gene polymorphisms determine the amount of TSHR expressed, which may in turn influence TRAb production. The FANTOM5 project identified six GD-associated single nucleotide polymorphisms (SNPs) within the enhancer regions...
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