Article
Genetic-epigenetic dysregulation of thymic TSH receptor gene expression triggers thyroid autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America - 26 Aug 2014
Stefan Mihaela, Wei Chengguo, Lombardi Angela, Li Cheuk Wun, Concepcion Erlinda S, Inabnet William B, Owen Randall, Zhang Weijia, Tomer Yaron
Abstract excerpt
Graves disease (GD) is an autoimmune condition caused by interacting genetic and environmental factors. Genetic studies have mapped several single-nucleotide polymorphisms (SNPs) that are strongly associated with GD, but the mechanisms by which they trigger disease are unknown. We hypothesized that epigenetic modifications induced by microenvironmental influences of cytokines can reveal the functionality of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.