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Mechanism of catalytic apparatus of human chitotriosidase-1 and its dual inactivation mode by the <i>first-in-class</i> OATD-01 inhibitor

2024-12-21

Abstract excerpt

Despite extensive research over the past three decades, there are still uncertainties regarding the catalytic mechanism of human chitotriosidase-1. To fill the gap, we reanalysed the structural information available for this enzyme. Based on the existing and new experimental data, complemented by multi-scale simulations, we modelled the full-length structure of human chitotriosidase-1 and proposed the general mode...

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Literature Corpus work
742514aa-279e-5f37-955d-1695eb4662df
DOI
10.1101/2024.12.18.628861
Open publication

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Mechanism of catalytic apparatus of human chitotriosidase-1 and its dual inactivation mode by the <i>first-in-class</i> OATD-01 inhibitorDOI 10.1101/2024.12.18.628861
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