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Article

Exploring the structural constraints at cleavage site of mucin 1 isoform through molecular dynamics simulation.

European biophysics journal : EBJ - 1 Jul 2015

Kumari J Lesitha Jeeva, Sudandiradoss C

Abstract excerpt

In silico alanine scanning mutagenesis on the cleavable isoform of mucin 1 revealed isoleucine 67 as one of the key factors contributing to the strain at the autoproteolytic cleavage site. In this study, we demonstrate the structural basis of isoleucine-induced rigidity towards the strain-driven autoproteolysis at G(-1)S(+1) cleavage site of mucin 1. We further evaluated the gain in flexibility upon isoleucine 67...

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Source

Identifiers

PMID: 25861899
DOI: 10.1007/s00249-015-1023-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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