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Metal Dependent Dynamic Equilibrium: A Regulatory Mechanism for M17 Aminopeptidases from <i>Plasmodium falciparum</i> and <i>Plasmodium vivax</i>

2020-10-08

Abstract excerpt

M17 leucyl aminopeptidases are metal-dependent exopeptidases that rely on oligomerization to diversify their functional roles. The M17 aminopeptidases from Plasmodium falciparum ( Pf A - M17) and Plasmodium vivax ( Pv -M17) function as catalytically active hexamers to acquire free amino acids from human hemoglobin and are drug targets for the design of novel anti-malarial agents. In this study, we found that...

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Literature Corpus work
10871735-e237-55ea-92ce-ef1ff33c4bd7
DOI
10.1101/2020.10.08.331538
Open publication

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Metal Dependent Dynamic Equilibrium: A Regulatory Mechanism for M17 Aminopeptidases from <i>Plasmodium falciparum</i> and <i>Plasmodium vivax</i>DOI 10.1101/2020.10.08.331538
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