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Article

Structural and mechanistic exploration of acid resistance: kinetic stability facilitates evolution of extremophilic behavior.

Journal of molecular biology - 4 May 2007

Kelch Brian A, Eagen Kyle P, Erciyas F Pinar, Humphris Elisabeth L, Thomason Adam R, Mitsuiki Shinji, Agard David A

Abstract excerpt

Kinetically stable proteins are unique in that their stability is determined solely by kinetic barriers rather than by thermodynamic equilibria. To better understand how kinetic stability promotes protein survival under extreme environmental conditions, we analyzed the unfolding behavior and determined the structure of Nocardiopsis alba Protease A (NAPase), an acid-resistant, kinetically stable protease, and...

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Identifiers

PMID: 17382344
DOI: 10.1016/j.jmb.2007.02.032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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