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SPINK1-COL18A1 crosstalk shapes epigenome and drives cancer stemness in pancreatic ductal adenocarcinoma

18 Aug 2026

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with an increasing incidence and extremely dismal prognosis. Discovery and mechanistic understanding of the genetic and epigenetic drivers of PDAC is therefore of critical importance. Here, we uncover serine protease inhibitor Kazal type 1 (SPINK1) as a putative determinant of clinical progression and demonstrate that it can have a non-canonical...

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PMID: 40093187
DOI: 10.1016/j.celrep.2026.117806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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