Article
Allelic effects on KLHL17 expression underlie a pancreatic cancer genome-wide association signal at chr1p36.33.
Nature communications - 30 Apr 2025
Connelly Katelyn E, Hullin Katherine, Abdolalizadeh Ehssan, Zhong Jun, Eiser Daina, O'Brien Aidan, Collins Irene, Das Sudipto, Duncan Gerard, Chanock Stephen J, Stolzenberg-Solomon Rachael Z, Klein Alison P, Wolpin Brian M, Hoskins Jason W, Andresson Thorkell, Smith Jill P, Amundadottir Laufey T
Abstract excerpt
Pancreatic Ductal Adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths in the U.S. Both rare and common germline variants contribute to PDAC risk. Here, we fine-map and functionally characterize a common PDAC risk signal at chr1p36.33 (tagged by rs13303010) identified through a genome wide association study (GWAS). One of the fine-mapped SNPs, rs13303160 (OR = 1.23 (95% CI 1.15-1.32),...
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