Article

Inhibition of the signal peptidase complex blocks cleavage of HTLV-1 ORF-I encoded p12 to p8 and impairs virus transmission

2025-03-17

Abstract excerpt

<title>Abstract</title> <p>Infection with the oncogenic delta-retrovirus Human T-cell Leukemia Virus Type 1 (HTLV-1) causes aggressive CD4+ T-cell malignancy or progressive neuroinflammatory disorders. The HTLV-1 accessory protein p8 is important for viral persistence and induces formation of cellular conduits, thereby enhancing HTLV-1 cell-to-cell transmission. p8 is a cleavage product of its precursor protein p...

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Literature Corpus work: 740cc974-dde3-5442-961d-3fabee2fa66c
DOI: 10.21203/rs.3.rs-6064775/v1

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Inhibition of the signal peptidase complex blocks cleavage of HTLV-1 ORF-I encoded p12 to p8 and impairs virus transmissionDOI 10.21203/rs.3.rs-6064775/v1Read

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