Article

Evasion of CARD8 Activation During HIV-1 Assembly

2025-05-19

Abstract excerpt

<h4>ABSTRACT</h4> As intracellular parasites, viruses must devise sophisticated mechanisms to produce and assemble viral components while suppressing activation of innate immune effectors. Here, we report that coordination of HIV-1 assembly by the viral polyprotein Gag suppresses inappropriately-timed protease (PR) activity to evade the PR activity sensor, CARD8. Employing mutants of Gag, we show that disruption...

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Literature Corpus work: 5bf05b59-a023-5231-89ec-7e90d56e0f99
DOI: 10.1101/2025.05.19.654850

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