Article

Signal peptidase complex mediates rotavirus VP7 processing and virion assembly

2025-11-04

Abstract excerpt

For viruses that replicate in the proximity of or bud at the endoplasmic reticulum (ER) associated membranes, proper processing of their glycoproteins is critical for successful infection. Rotavirus outer capsid protein VP7 is an ER-resident protein. However, its N-terminal signal peptide is removed by an unknown proteolytic mechanism. In this study, we leveraged tandem affinity purification followed by high-resol...

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Literature Corpus work: c600ed9b-da4f-59bc-9a11-360da62e9eb6
DOI: 10.1101/2025.11.04.686468

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