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Article

Evasion of CARD8 activation during HIV-1 assembly.

Science advances - 14 Nov 2025

Hughes Ivy K, Hood James B, Quiñones-Molina Andrés A, Akiyama Hisashi, Gummuluru Suryaram

Abstract excerpt

As intracellular parasites, viruses must devise sophisticated mechanisms to produce and assemble viral components while suppressing activation of innate immune effectors. Here, we report that coordination of HIV-1 assembly by the viral polyprotein Gag suppresses inappropriately timed protease (PR) activity to evade the PR activity sensor, caspase recruitment domain-containing protein 8 (CARD8). Using mutants of...

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Topics

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Share to CARD Signaling Adaptor Proteins
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

Share to HIV Protease

Share to Immune Evasion

Share to Inflammasomes

Share to Interleukin-1beta

Share to Virus Assembly

Source

Open in PubMed Open full text

Identifiers

PMID: 41223282
DOI: 10.1126/sciadv.adz1069
PMCID: PMC12609157

Genes

CARD8
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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