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Article

In vivo genetic mutations define predominant functions of the human T-cell leukemia/lymphoma virus p12I protein.

Blood - 16 Apr 2009

Fukumoto Risaku, Andresen Vibeke, Bialuk Izabela, Cecchinato Valentina, Walser Jean-Claude, Valeri Valerio W, Nauroth Julie M, Gessain Antoine, Nicot Christophe, Franchini Genoveffa

Abstract excerpt

The human T-cell leukemia/lymphoma virus type 1 (HTLV-1) ORF-I encodes a 99-amino acid hydrophobic membrane protein, p12(I), that affects receptors in different cellular compartments. We report here that proteolytic cleavage dictates different cellular localization and functions of p12(I). The removal of a noncanonical endoplasmic reticulum (ER) retention/retrieval signal within the amino terminus of p12(I) is...

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Identifiers

PMID: 18791162
DOI: 10.1182/blood-2008-04-146928
PMCID: PMC2670790

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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