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Article

Context-dependent autoprocessing of human immunodeficiency virus type 1 protease precursors.

PloS one - 1 Jan 2018

Tien ChihFeng, Huang Liangqun, Watanabe Susan M, Speidel Jordan T, Carter Carol A, Chen Chaoping

Abstract excerpt

HIV-1 protease autoprocessing is responsible for liberation of free mature protease (PR) from the Gag-Pol polyprotein precursor. A cell-based model system was previously developed to examine the autoprocessing mechanism of fusion precursors carrying the p6*-PR miniprecursor sandwiched between various proteins or epitopes. We here report that precursor autoprocessing is context-dependent as its activity and...

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PMID: 29338056
DOI: 10.1371/journal.pone.0191372
PMCID: PMC5770051

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MBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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