Article

Programming T cells for Early Cancer Detection with Customized Protease-Activatable Receptors

2026-01-20

Abstract excerpt

Early cancer detection has the potential to reduce cancer mortality, yet endogenous tumor-shed biomarkers lack sensitivity for early-stage disease. We report OncoSCOUT, a cancer detection strategy using T cells engineered with protease-activatable receptors (PARs) that conditionally recognize tumor cells and release a synthetic biomarker for detection in urine. These PARs comprise masked synthetic Notch receptors...

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Literature Corpus work: 73fc3e7c-3993-5013-b9fc-c4ed46078b62
DOI: 10.64898/2026.01.16.699939

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