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Article

Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.

Nature communications - 6 Jul 2018

Kaminski Andrea M, Tumbale Percy P, Schellenberg Matthew J, Williams R Scott, Williams Jason G, Kunkel Thomas A, Pedersen Lars C, Bebenek Katarzyna

Abstract excerpt

DNA ligase IV (LigIV) performs the final DNA nick-sealing step of classical nonhomologous end-joining, which is critical for immunoglobulin gene maturation and efficient repair of genotoxic DNA double-strand breaks. Hypomorphic LigIV mutations cause extreme radiation sensitivity and immunodeficiency in humans. To better understand the unique features of LigIV function, here we report the crystal structure of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29980672
DOI: 10.1038/s41467-018-05024-8
PMCID: PMC6035275

Genes

LIG4

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