Article

Sex of donor cell and reprogramming conditions predict the extent and nature of imprinting defects in mouse iPSCs

2020-11-20

Abstract excerpt

<h4>ABSTRACT</h4> Reprogramming of somatic cells into induced Pluripotent Stem Cells (iPSCs) is a major leap towards personalized approaches to disease modelling and cell-replacement therapies. However, we still lack the ability to fully control the epigenetic status of iPSCs, which is a major hurdle for their downstream applications. A sensible indicator for epigenetic fidelity is genomic imprinting, a phenomeno...

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Literature Corpus work: 73eec127-33cd-5204-9bb4-ce3c2aafa6f2
DOI: 10.1101/2020.11.20.370973

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