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Conservation of DNA Methylation Programming Between Mouse and Human Gametes and Preimplantation Embryos

27 Jul 2016

Abstract excerpt

In mice, assisted reproductive technologies (ARTs) applied during gametogenesis and preimplantation development can result in disruption of genomic imprinting. In humans, these technologies and/or subfertility have been linked to perturbations in genomic imprinting. To understand how ARTs and infertility affect DNA methylation, it is important to understand DNA methylation dynamics and the role of regulatory...

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PMID: 27465133
DOI: 10.1095/biolreprod.116.140319

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