Article

PROX1 loss in adult mouse Schlemm's canal causes permanent ocular hypertension

2025-11-14

Abstract excerpt

Glaucoma is associated with ocular hypertension and lowering intraocular pressure is a key objective of glaucoma therapies. Recent studies have established a role for the Schlemm's canal endothelium in this pressure increase and have shown it to have a unique, lymphatic-like, hybrid phenotype. However, the role of these lymphatic phenotypes in the adult canal remains uncertain. Long-term functional studies have be...

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Literature Corpus work: 8391a9b3-c4aa-5b75-bfff-8dccf6baa4f8
DOI: 10.1101/2025.11.13.688015

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