Article

YAP/TAZ inactivation with simvastatin attenuates glucocorticoid-induced human trabecular meshwork cell dysfunction

2022-09-28

Abstract excerpt

<h4>Purpose</h4> Impairment of the trabecular meshwork (TM) is the principal cause of increased outflow resistance in the glaucomatous eye. Yes-associated protein (YAP) and transcriptional coactivator with PDZ binding motif (TAZ) are emerging as potential mediators of TM cell/tissue dysfunction. Furthermore, YAP/TAZ activity was recently found to be controlled by the mevalonate pathway in non-ocular cells. Clinic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c72ea3d1-4fa6-57bc-b878-b4e9180c5d69
DOI: 10.1101/2022.09.27.509788

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

YAP/TAZ inactivation with simvastatin attenuates glucocorticoid-induced human trabecular meshwork cell dysfunctionDOI 10.1101/2022.09.27.509788Read

Macrophage Migration Inhibitory Factor (MIF)-CD74 Signaling Pathway Mediates Trabecular Meshwork Dysfunction in GlaucomaSemantic proximity Read

Transcriptomic Atlas of Human Trabecular Meshwork Uncovers the Cellular Landscape and Provides Insights into Glaucoma PathophysiologySemantic proximity Read

Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells.Semantic proximity Read

Genome-wide Expression Profiling and Pathway Analysis in Cyclic Stretched Human Trabecular Meshwork CellsSemantic proximity Read

Genome-wide transcriptome profiling of human trabecular meshwork cells treated with TGF-β2Semantic proximity Read

Wnt Activation After Inhibition Restores Trabecular Meshwork Cells Toward a Normal Phenotype.Semantic proximity Read

Genome-Wide Transcriptome Profiling of Human Trabecular Meshwork Cells Treated with TGF-β2.Semantic proximity Read

A Comparative Genome-Wide Transcriptome Analysis of Glucocorticoid Responder and Non-Responder Primary Human Trabecular Meshwork CellsSemantic proximity Read

A Comparative Genome-wide Transcriptome Analysis of Glucocorticoid Responder and Non-Responder Primary Human Trabecular Meshwork CellsSemantic proximity Read

The Effects of ROCK Inhibitor on Prevention of Dexamethasone-Induced Glaucoma Phenotype in Human Trabecular Meshwork Cells.Semantic proximity Read

Human trabecular meshwork cells exhibit several characteristics of, but are distinct from, adipose-derived mesenchymal stem cells.Semantic proximity Read

Time-dependent Glucocorticoid-Induced Transcriptomic Changes in Human Trabecular Meshwork and Schlemm’s CanalSemantic proximity Read