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Dysregulation of septin cytoskeletal organization in the trabecular meshwork contributes to ocular hypertension

5 Dec 2024

Abstract excerpt

Ocular hypertension, believed to result partly from increased contractile activity, cell adhesive interactions, and stiffness within the trabecular meshwork (TM), is a major risk factor for glaucoma, a leading cause of blindness. However, the identity of molecular mechanisms governing organization of actomyosin and cell adhesive interactions in the TM remains limited. Based on our previous findings, in which...

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PMID: 39641270
DOI: 10.1172/jci.insight.179468

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