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Article

Differential roles of FOXC2 in the trabecular meshwork and Schlemm’s canal in glaucomatous pathology

6 Jul 2023

Abstract excerpt

Impaired development and maintenance of Schlemm’s canal (SC) are associated with perturbed aqueous humor outflow and intraocular pressure. The angiopoietin (ANGPT)/TIE2 signaling pathway regulates SC development and maintenance, whereas the molecular mechanisms of crosstalk between SC and the neural crest (NC)-derived neighboring tissue, the trabecular meshwork (TM), are poorly understood. Here, we show...

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PMID: 37414529
DOI: 10.26508/lsa.202201721

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