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Mechanical Strain Regulates Myofibroblast Differentiation of Human Scleral Fibroblasts by YAP

30 Sept 2021

Abstract excerpt

Scleral extracellular matrix (ECM) remodeling is thought to play a critical role in the pathogenesis of glaucoma. Mechanical strain induced by elevated intraocular pressure can promote myofibroblast differentiation of fibroblasts and result in scleral ECM remodeling; however, the underlying mechanism remains poorly understood. Yes-associated protein (YAP) is a mechanosensory protein and the key downstream...

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Share to Corneal surgery and disorders
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Identifiers

PMID: 34658907
DOI: 10.3389/fphys.2021.712509

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