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Article

Single-cell transcriptomics identifies senescence-associated secretory phenotype (SASP) features of testicular aging in human.

Aging - 12 Feb 2024

He Junxian, Li Jindong, Li Yanqing, Xu Zhenhan, Ma Menghui, Chen Haicheng, Chen Peigen, Lv Linyan, Shang Xuejun, Liu Guihua

Abstract excerpt

The male reproductive system experiences degradation with age, predominantly impacting the testes. Testicular aging can result in failure to produce physiological testosterone levels, normal sperm concentrations, or both. However, we cannot predict the onset of testicular aging in advance. Using single-cell RNA sequencing (scRNA-seq) from Gene Expression Omnibus (GEO) database, we conducted cell-cell...

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PMID: 38349859
DOI: 10.18632/aging.205538
PMCID: PMC10929807

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