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Article

Genome-wide CRISPR and small-molecule screens uncover targetable dependencies in ATRT

2020-12-09

Abstract excerpt

<h4>Summary</h4> Atypical teratoid rhabdoid tumors (ATRT) are incurable high-grade pediatric brain tumors. Concepts for molecular-driven therapies in ATRTs lag behind, mainly due to the absence of actionable genetic alterations. We performed genome-wide CRISPR/Cas9 knockout screens in six human ATRT cell lines and identified a total of 671 context-specific essential genes. Based on these genetic dependencies, we...

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Identifiers and source

Literature Corpus work
739fa71b-df82-5531-a8e1-def44a571149
DOI
10.1101/2020.12.09.417378
Open publication

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