Article
A first-generation pediatric cancer dependency map.
Nature genetics - 1 Apr 2021
Dharia Neekesh V, Kugener Guillaume, Guenther Lillian M, Malone Clare F, Durbin Adam D, Hong Andrew L, Howard Thomas P, Bandopadhayay Pratiti, Wechsler Caroline S, Fung Iris, Warren Allison C, Dempster Joshua M, Krill-Burger John M, Paolella Brenton R, Moh Phoebe, Jha Nishant, Tang Andrew, Montgomery Philip, Boehm Jesse S, Hahn William C, Roberts Charles W M, McFarland James M, Tsherniak Aviad, Golub Todd R, Vazquez Francisca, Stegmaier Kimberly
Abstract excerpt
Exciting therapeutic targets are emerging from CRISPR-based screens of high mutational-burden adult cancers. A key question, however, is whether functional genomic approaches will yield new targets in pediatric cancers, known for remarkably few mutations, which often encode proteins considered challenging drug targets. To address this, we created a first-generation pediatric cancer dependency map representing 13...
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