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Advancing biology-based therapeutic approaches for atypical teratoid rhabdoid tumors

2 Mar 2020

Abstract excerpt

Atypical teratoid rhabdoid tumor (ATRT) is a rare, highly malignant central nervous system cancer arising in infants and younger children, historically considered to be homogeneous, monogenic, and incurable. Recent use of intensified therapies has modestly improved survival for ATRT; however, a majority of patients will still succumb to their disease. While ATRTs almost universally exhibit loss of SMARCB1...

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PMID: 32129445
DOI: 10.1093/neuonc/noaa046

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