Article

Sugar distributions on gangliosides guide the formation and stability of amyloid-β oligomers

2023-05-10

Abstract excerpt

Aggregation of Aβ peptides has been known as a key contributor to the etiology of Alzheimer’s disease. Being intrinsically disordered, the monomeric Aβ is susceptible to conformational excursions, especially in the presence of key interacting partners such as membrane lipids, to adopt specific aggregation pathways. Furthermore, key components such as gangliosides in membranes and lipid rafts are known to play impo...

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Literature Corpus work: 54ac10da-0a61-5e76-b47f-1e3e77028d83
DOI: 10.1101/2023.05.09.540003

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