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Combination of genetically engineered T cells and immune checkpoint blockade for the treatment of cancer

1 Jan 2022

Abstract excerpt

Immune checkpoint (IC) blockade using monoclonal antibodies is currently one of the most successful immunotherapeutic interventions to treat cancer. By reinvigorating antitumor exhausted T cells, this approach can lead to durable clinical responses. However, the majority of patients either do not respond or present a short-lived response to IC blockade, in part due to a scarcity of tumor-specific T cells within...

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PMID: 35919489
DOI: 10.1093/immadv/ltac005

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