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Article

Redirecting Specificity of T-Cell Populations For CD19 Using the <i>Sleeping Beauty</i> System

15 Apr 2008

Abstract excerpt

Genetic modification of clinical-grade T cells is undertaken to augment function, including redirecting specificity for desired antigen. We and others have introduced a chimeric antigen receptor (CAR) to enable T cells to recognize lineage-specific tumor antigen, such as CD19, and early-phase human trials are currently assessing safety and feasibility. However, a significant barrier to next-generation clinical...

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PMID: 18413766
DOI: 10.1158/0008-5472.can-07-5600

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