Article

Scalable, optically-responsive human neuromuscular junction model reveals convergent mechanisms of synaptic dysfunction in familial ALS

2024-01-12

Abstract excerpt

<h4>ABSTRACT</h4> Neuromuscular junctions (NMJs) are specialized synapses that mediate communication between motor neurons and skeletal muscles and are essential for movement. The degeneration of this system can lead to symptoms observed in neuromuscular and motor neuron diseases. Studying these synapses and their degeneration has proven challenging. Prior NMJ studies heavily relied upon the use of mouse, chick,...

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Literature Corpus work: 73342d6f-9267-5e5d-b861-f78c04270711
DOI: 10.1101/2024.01.11.575304

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