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Article

ALS mutations in both human skeletal muscle and motoneurons differentially affects neuromuscular junction integrity and function.

Biomaterials - 1 Oct 2022

Badu-Mensah Agnes, Guo Xiufang, Nimbalkar Siddharth, Cai Yunqing, Hickman James J

Abstract excerpt

There is evidence for the involvement of human skeletal muscle (hSKM) in ALS neuromuscular junction (NMJ) dysfunction. However, the specific avenue by which the hSKM contributes to NMJ disruption is not well understood due to limited human-based studies performed to investigate the subject. Thus, hSKM and human motoneurons (hMN) generated from induced pluripotent stem cells of healthy individuals (WT) and ALS...

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PMID: 36084484
DOI: 10.1016/j.biomaterials.2022.121752

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