Article

A Cultured Sensorimotor Organoid Model Forms Human Neuromuscular Junctions

2021-03-03

Abstract excerpt

Human induced pluripotent stem cells (iPSCs) hold promise for modeling diseases in individual human genetic backgrounds and thus for developing precision medicine. Here, we generate sensorimotor organoids containing physiologically functional neuromuscular junctions (NMJs) within a cultured organoid system and apply the model to different subgroups of amyotrophic lateral sclerosis (ALS). Using a range of molecular...

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Literature Corpus work: 3eba0949-dc2a-586b-8bc9-85fd2327965d
DOI: 10.1101/2021.03.03.433128

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