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Article

Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions.

Nature communications - 6 Aug 2021

Pereira João D, DuBreuil Daniel M, Devlin Anna-Claire, Held Aaron, Sapir Yechiam, Berezovski Eugene, Hawrot James, Dorfman Katherine, Chander Vignesh, Wainger Brian J

Abstract excerpt

Human induced pluripotent stem cells (iPSC) hold promise for modeling diseases in individual human genetic backgrounds and thus for developing precision medicine. Here, we generate sensorimotor organoids containing physiologically functional neuromuscular junctions (NMJs) and apply the model to different subgroups of amyotrophic lateral sclerosis (ALS). Using a range of molecular, genomic, and physiological...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34362895
DOI: 10.1038/s41467-021-24776-4
PMCID: PMC8346474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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