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A 3D cell culture system for bioengineering human neuromuscular junctions to model ALS

14 Feb 2023

Abstract excerpt

The signals that coordinate and control movement in vertebrates are transmitted from motoneurons (MNs) to their target muscle cells at neuromuscular junctions (NMJs). Human NMJs display unique structural and physiological features, which make them vulnerable to pathological processes. NMJs are an early target in the pathology of motoneuron diseases (MND). Synaptic dysfunction and synapse elimination precede MN...

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PMID: 36866276
DOI: 10.3389/fcell.2023.996952

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