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Article

A Human‐Based Functional NMJ System for Personalized ALS Modeling and Drug Testing

11 Aug 2020

Abstract excerpt

Loss of the neuromuscular junction (NMJ) is an early and critical hallmark in all forms of ALS. The study design was to develop a functional NMJ disease model by integrating motoneurons (MNs) differentiated from multiple ALS-patients' induced pluripotent stem cells (iPSCs) and primary human muscle into a chambered system. NMJ functionality was tested by recording myotube contractions while stimulating MNs by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33709015
DOI: 10.1002/adtp.202000133

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