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A Monolayer System for the Efficient Generation of Motor Neuron Progenitors and Functional Motor Neurons from Human Pluripotent Stem Cells.

Cells - 7 May 2021

Cutarelli Alessandro, Martínez-Rojas Vladimir A, Tata Alice, Battistella Ingrid, Rossi Daniela, Arosio Daniele, Musio Carlo, Conti Luciano

Abstract excerpt

Methods for the conversion of human induced pluripotent stem cells (hiPSCs) into motor neurons (MNs) have opened to the generation of patient-derived in vitro systems that can be exploited for MN disease modelling. However, the lack of simplified and consistent protocols and the fact that hiPSC-derived MNs are often functionally immature yet limit the opportunity to fully take advantage of this technology,...

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Cell Differentiation
Cells, Cultured
CRISPR and Genetic Engineering
Induced Pluripotent Stem Cells
Motor Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pluripotent Stem Cells Research

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PMID: 34066970
DOI: 10.3390/cells10051127
PMCID: PMC8151197

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