Article

Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families

2025-12-09

Abstract excerpt

Life expectancy has steadily increased in the last two centuries, while healthspan has been lagging behind. Survival into extreme ages strongly clusters within families which often exhibit a delayed onset of (multi)morbidity, yet the underlying protective genetic mechanisms are still largely undefined. We performed affected sib-pair linkage analysis in 212 sibships enriched for ancestral longevity and identified f...

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Identifiers and source

Literature Corpus work: 73308973-62ae-5370-a991-7e5e21deac4a
DOI: 10.64898/2025.12.04.689698

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