Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants.

Neurobiology of disease - 1 Sept 2020

Miller Justin B, Ward Elizabeth, Staley Lyndsay A, Stevens Jeffrey, Teerlink Craig C, Tavana Justina P, Cloward Matthew, Page Madeline, Dayton Louisa, Cannon-Albright Lisa A, Kauwe John S K

Abstract excerpt

BACKGROUND: Longevity as a phenotype entails living longer than average and typically includes living without chronic age-related diseases. Recently, several common genetic components to longevity have been identified. This study aims to identify additional genetic variants associated with longevity using unique and powerful analyses of pedigrees with a statistical excess of healthy elderly individuals identified...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CCAAT-Enhancer-Binding Proteins

Share to Genetic Variation

Share to Genotype

Share to Longevity

Share to Pedigree

Source

Open in PubMed Open full text

Identifiers

PMID: 32574725
DOI: 10.1016/j.nbd.2020.104972
PMCID: PMC7461696

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants.PMID 32574725Read ↗

Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variantsSemantic proximity Read ↗

Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study.Semantic proximity Read ↗

Exome sequencing of three cases of familial exceptional longevity.Semantic proximity Read ↗

Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity.Semantic proximity Read ↗

Exome and whole genome sequencing in aging and longevity.Semantic proximity Read ↗

Rare genetic coding variants associated with human longevity and protection against age-related diseases.Semantic proximity Read ↗

LongevityMap: a database of human genetic variants associated with longevity.Semantic proximity Read ↗

A genome-wide study replicates linkage of 3p22-24 to extreme longevity in humans and identifies possible additional loci.Semantic proximity Read ↗

Genetic associations with human longevity are enriched for oncogenic genesSemantic proximity Read ↗

Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study.Semantic proximity Read ↗

Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity.Semantic proximity Read ↗

German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.