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Article

Age and early life adversity shape heterogeneity of the epigenome across tissues in macaques

2025-07-18

Abstract excerpt

Age and early life adversity (ELA) are both key determinants of health, but whether they target similar physiological mechanisms across the body is unknown due to limited multi-tissue datasets from well-characterized cohorts. We generated DNA methylation (DNAm) profiles across 14 tissues in 237 semi-free ranging rhesus macaques, with records of naturally occurring ELA. We show that age-associated DNAm variation is...

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Identifiers and source

Literature Corpus work
961752a4-608c-5445-93df-c268e4f4c1b4
DOI
10.1101/2025.07.13.664445
Open publication

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Age and early life adversity shape heterogeneity of the epigenome across tissues in macaquesDOI 10.1101/2025.07.13.664445
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