Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rewired type I IFN signaling is linked to age-dependent differences in COVID-19

1 Aug 2025

Abstract excerpt

Advanced age is the most important risk factor for severe disease or death from COVID-19, but a thorough mechanistic understanding of the molecular and cellular underpinnings is lacking. Multi-omics analysis of 164 samples from SARS-CoV-2-infected persons aged 1 to 84 years reveals a rewiring of type I interferon (IFN) signaling with a gradual shift from signal transducer and activator of transcription 1 (STAT1)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Clinical Research Studies
Share to interferon and immune responses
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40834853
DOI: 10.1016/j.xcrm.2025.102285

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rewired type I IFN signaling is linked to age-dependent differences in COVID-19PMID 40834853Read ↗

Host-Microbe Multiomic Profiling Reveals Age-Dependent COVID-19 ImmunopathologySemantic proximity Read ↗

Specialized interferon action in COVID-19Semantic proximity Read ↗

Longitudinal analyses reveal age-specific immune correlates of COVID-19 severitySemantic proximity Read ↗

Single-Cell Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19Semantic proximity Read ↗

Multi-omic Profiling Reveals Early Immunological Indicators for Identifying COVID-19 ProgressorsSemantic proximity Read ↗

A human circulating immune cell landscape in aging and COVID-19Semantic proximity Read ↗

Immune perturbations induced by SARS-CoV2 in infants vary with disease severity and differ from adults’ responsesSemantic proximity Read ↗

Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participantsSemantic proximity Read ↗

Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individualsSemantic proximity Read ↗

Multi-omics approach identifies novel age-, time- and treatment-related immunopathological signatures in MIS-C and pediatric COVID-19Semantic proximity Read ↗

Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19Semantic proximity Read ↗

Multi-Omics Integration Reveals Only Minor Long-Term Molecular and Functional Sequelae in Immune Cells of Individuals Recovered From COVID-19Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.