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Article

Rewired type I IFN signaling is linked to age-dependent differences in COVID-19

1 Aug 2025

Abstract excerpt

Advanced age is the most important risk factor for severe disease or death from COVID-19, but a thorough mechanistic understanding of the molecular and cellular underpinnings is lacking. Multi-omics analysis of 164 samples from SARS-CoV-2-infected persons aged 1 to 84 years reveals a rewiring of type I interferon (IFN) signaling with a gradual shift from signal transducer and activator of transcription 1 (STAT1)...

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COVID-19 Clinical Research Studies
interferon and immune responses
SARS-CoV-2 and COVID-19 Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40834853
DOI: 10.1016/j.xcrm.2025.102285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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