Article

Coordinated variation in the immune systems and microbiomes of healthy humans is linked to tonic interferon states

2024-12-03

Abstract excerpt

Human immune systems are highly variable, with most variation attributable to non-genetic sources. The gut microbiome crucially shapes the immune system; however, its relationship with the baseline immune states of healthy humans remains incompletely understood. Therefore, we performed multi-omic profiling of 110 healthy participants through the ImmunoMicrobiome study. A factor-based integrative approach identifie...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f8f067bd-7a09-5089-aa7b-803e9a822ce9
DOI: 10.1101/2024.11.27.625750

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Coordinated variation in the immune systems and microbiomes of healthy humans is linked to tonic interferon statesDOI 10.1101/2024.11.27.625750Read

Harmony Within: Unravelling the Microbiome–Immune System Symbiosis for HealthSemantic proximity Read

Integrative Multi-Omics Analysis of Gut Microbiota Dysbiosis and Host–Microbiome Interaction Mechanisms in HypertensionSemantic proximity Read

Multi-omics: Differential expression of IFN-γ results in distinctive mechanistic features linking chronic inflammation, gut dysbiosis, and autoimmune diseasesSemantic proximity Read

Bridging immunotypes and enterotypes using a systems immunology approachSemantic proximity Read

Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses.Semantic proximity Read

Associations between host microbiome and inflammation suggest role for host microbiome in driving COVID-19 disease severitySemantic proximity Read

Systems-level longitudinal immune profiling reveals individualized immunotypes and genetic associationsSemantic proximity Read

Support for the Microgenderome: Associations in a Human Clinical PopulationSemantic proximity Read

Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation in health and diseaseSemantic proximity Read

Attomolar fecal cytokine profiling reveals gut immune dynamics and disease statesSemantic proximity Read

Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy AdultsSemantic proximity Read

Gut microbiome-mediated metabolism effects on immunity in rural and urban African populationsSemantic proximity Read