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Article

Pannexin 1 Transgenic Mice: Human Diseases and Sleep-Wake Function Revision.

International journal of molecular sciences - 17 May 2021

Battulin Nariman, Kovalzon Vladimir M, Korablev Alexey, Serova Irina, Kiryukhina Oxana O, Pechkova Marta G, Bogotskoy Kirill A, Tarasova Olga S, Panchin Yuri

Abstract excerpt

In humans and other vertebrates pannexin protein family was discovered by homology to invertebrate gap junction proteins. Several biological functions were attributed to three vertebrate pannexins members. Six clinically significant independent variants of the PANX1 gene lead to human infertility and oocyte development defects, and the Arg217His variant was associated with pronounced symptoms of primary ovarian...

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Identifiers

PMID: 34067798
DOI: 10.3390/ijms22105269
PMCID: PMC8155943

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