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Article

Splice variants of the P2X7 receptor reveal differential agonist dependence and functional coupling with pannexin-1.

Journal of cell science - 15 Aug 2012

Xu Xing Jian, Boumechache Miyyada, Robinson Lucy E, Marschall Viola, Gorecki Dariusz C, Masin Marianela, Murrell-Lagnado Ruth D

Abstract excerpt

P2X7 receptors function as ATP-gated cation channels but also interact with other proteins as part of a larger signalling complex to mediate a variety of downstream responses that are dependent upon the cell type in which they are expressed. Receptor-mediated membrane permeabilization to large molecules precedes the induction of cell death, but remains poorly understood. The mechanisms that underlie differential...

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Identifiers

PMID: 22553206
DOI: 10.1242/jcs.099374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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