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Article

Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.

The Journal of pharmacology and experimental therapeutics - 1 Feb 2009

Ma Weihong, Hui Hui, Pelegrin Pablo, Surprenant Annmarie

Abstract excerpt

Pannexin (Panx) 1 is a widely expressed protein that shares structural, but not amino acid, homology with gap junction proteins, the connexins. Panx1 does not form gap junctions in mammalian cells, but it may function as a plasma membrane hemichannel. Little is known of the pharmacological proper...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19023039
DOI: 10.1124/jpet.108.146365
PMCID: PMC2682283

Genes

PANX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19023039-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.PMID 19023039Read ↗

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A Germline Variant in the PANX1 Gene Has Reduced Channel Function and Is Associated with Multisystem DysfunctionSemantic proximity Read ↗

Pannexins, a family of gap junction proteins expressed in brainSemantic proximity Read ↗

<i>Panx1</i> channels promote both anti- and pro-seizure-like activities in the zebrafish via <i>p2rx7</i> receptors and ATP signalingSemantic proximity Read ↗

The Pannexin1 membrane channel: distinct conformations and functions.Semantic proximity Read ↗

A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP.Semantic proximity Read ↗

Structures of human pannexin 1 reveal ion pathways and mechanism of gating.Semantic proximity Read ↗

Pannexin 1 influences lineage specification of human iPSCsSemantic proximity Read ↗

Splice variants of the P2X7 receptor reveal differential agonist dependence and functional coupling with pannexin-1.Semantic proximity Read ↗

Inhibition of PANX1 Channels Reduces the Malignant Properties of Human High-Risk NeuroblastomaSemantic proximity Read ↗

Allosteric modulation of ATP-gated P2X receptor channels.Semantic proximity Read ↗

S-nitrosylation inhibits pannexin 1 channel function.Semantic proximity Read ↗

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