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<i>Panx1</i> channels promote both anti- and pro-seizure-like activities in the zebrafish via <i>p2rx7</i> receptors and ATP signaling

2021-06-04

Abstract excerpt

The molecular mechanisms of excitation-inhibition imbalances promoting seizure generation in epilepsy patients are not fully understood. Experimental evidence suggests that Pannexin1 ( Panx1 ), an ATP release channel, modulates excitability of the brain. In this report, we have performed behavioral and molecular phenotyping experiments on zebrafish larvae bearing genetic or pharmacological knockouts of panx1a or...

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Literature Corpus work
8ec3d552-3a4e-5405-bbc5-58c08a66b81d
DOI
10.1101/2021.06.03.446992
Open publication

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