Article

Multi-omics analysis of keratinocytes reveals dermokine-dependent regulation of cell-cell adhesion via p120

2025-01-13

Abstract excerpt

<h4>Summary</h4> Loss of keratinocyte differentiation is a leading cause in several skin diseases and needs to be controlled in adult homeostasis by for instance growth factors and proteases. Among them, we studied the role of isoform-rich dermokine – a wound- and tumour-related matrix metalloproteinase 10 substrate – via functional multi-omics. We generated dermokine isoform-dependent keratinocyte knockouts and...

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Literature Corpus work: 730481e6-bf80-5ca4-9035-e51e1c25caa8
DOI: 10.1101/2025.01.10.632346

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